Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition

DOI: 10.1021/jm00121a015

Source and publish data:

Journal of Medicinal Chemistry p. 73 - 76 (1989)

Update date:2022-08-04

Topics:

Authors:

Scheiner

Geer Geer

Bucknor Bucknor

Imbach Imbach

Schinazi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a015

An acyclic derivative of 3'-azido-3'-deoxythymidine, (R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C(3')-C(4') bond were similarly obtained.

Full text of DOI:10.1021/jm00121a015

Products guided by the article

Product name:1-[3-hydroxy-1-(2-hydroxyethoxy)propyl]-5-methylpyrimidine-2,4(1H,3H)-dione

Cas No:117143-02-9

R&D Labs maybe for 117143-02-9

ANTAI BIO-TECH CO LTD

website:http://www.antaibio.com

Contact:86-21-60939051,60939771

Address:1518#,ZHANGYANG ROAD
Xinxiang Junlong Biological Technology Co., Ltd.

website:https://junlongbio.lookchem.com/

Contact:86-13525059581

Address:Xinxiang City, Henan Province
Chengdu Gelipu Biotechnology Co., Ltd.

website:http://www.glp-china.com

Contact:86-28-82610909

Address:chegndu
SEA BRGIHT INDUSTRY CO.,LIMITED

Contact:0086 755 8622 3990

Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Jiangsu Taihu New Materials Holding Co., Ltd

Contact:+86-519-86160108

Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China

Relevant to this article

trans-2 addition pattern to power charge transfer in dendronized metalloporphyrin C₆₀ conjugates

Doi:10.1021/ja9029686
(2009)
Facile and efficient synthesis of benzo[b][1,5]diazepines by three-component coupling of aromatic diamines, Meldrum's acid, and isocyanides catalyzed by Fe₃O₄ nanoparticles

Doi:10.1007/s11164-014-1915-z
(2015)
Development of potential nonsteroidal antiandrogens: N-(4-nitro-3-trifluoromethylphenyl)-cyclohexanoylamides and -benzamides and N-(3,4-dichlorophenyl)- and N-(3,4,5-trichlorophenyl)-benzamides

Doi:10.1002/ardp.19883210710
(1988)
Preparation of Hindered Styrenes and Arylacetylenes

Doi:10.1021/jo00262a053
(1989)
Microwave-assisted synthesis and antifungal activity of 2,5-Disubstituted-1,3,4-oxadiazoles containing azulene moiety

Doi:10.1080/00397910802654658
(2009)
Application of the addition of triorganozincates to N-(tert-butanesulfinyl)imines to the enantioselective synthesis of α-amino acids

Doi:10.1016/j.tetlet.2009.05.008
(2009)

Article Doi