Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition

DOI: 10.1021/jm00121a015

Source and publish data:

Journal of Medicinal Chemistry p. 73 - 76 (1989)

Update date:2022-08-04

Topics:

Authors:

Scheiner

Geer Geer

Bucknor Bucknor

Imbach Imbach

Schinazi

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Article abstract of DOI:10.1021/jm00121a015

An acyclic derivative of 3'-azido-3'-deoxythymidine, (R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C(3')-C(4') bond were similarly obtained.

Full text of DOI:10.1021/jm00121a015

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Product name:1-[3-hydroxy-1-(2-hydroxyethoxy)propyl]-5-methylpyrimidine-2,4(1H,3H)-dione

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