Synthesis p. 1431 - 1436 (2009)
Update date:2022-08-05
Topics:
Chen, Mu-Wang
Zhang, Xing-Guo
Zhong, Ping
Hu, Mao-Lin
A highly practical method for the synthesis of fluorinated benzimidazoles was developed by CuI/TMEDA-catalyzed cross-coupling reaction of N-(2-haloaryl)trifluoroacetimidoyl chlorides with primary amines. The present double amination process tolerates the
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