Synthesis and Characterisation of the Sodium and Lithium Cryptates of Macrobicyclic Ligands Incorporating Pyridine, Bipyridine, and Biisoquinoline Units

Article abstract of DOI:10.1002/hlca.19880710515

Synthetic procedures have been developed for the preparation of sodium and lithium cryptates of the macrobicyclic ligands 1-11 containing pyridine, bipyridine, and biisoquinoline groups.They involve stepwise construction of the bicyclic system as well as direct macrobicyclisation procedures (Scheme 1) and give access to both symmetrical and dissymmetrical structures.Marked cation template effects have been found that facilitate the cyclisation processes.The ligands 1-11 were isolated as their cryptates with Na⁺ or Li⁺ cations.