Synthesis and Radioprotective Activity of Dipeptide Cysteamine and Cystamine Derivatives

Article abstract of DOI:10.1021/jm00122a004

Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as canditate radioprotector agents.Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate.One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).