Journal of Medicinal Chemistry p. 297 - 301 (1989)
Update date:2022-08-02
Topics:
Oiry, Joel
Pue, Jean Y.
Imbach, Jean L.
Fatome, Marc
Sentenac-Roumanou, Henry
Some N-(dipeptidyl)-S-acetylcysteamine and N,N'-(dipeptidyl)cystamine salt derivatives were synthesized and evaluated as canditate radioprotector agents.Toxicity and radioprotective activity as the dose reduction factor (DRF) were determined in vivo on mice and compared to N-glycyl-S-acetylcysteamine trifluoroacetate.One of the most interesting compounds of this series was N-glycylglycyl-S-acetylcysteamine trifluoroacetate (8).
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