Preparation of carbon-14 labeled (3R)-7-hydroxy-N-(1S)-1-{[(3R,4R)-4-(3- hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl-1,2,3, 4-tetrahydroisoquinolinecarboxamide (JDTic)

Article abstract of DOI:10.1002/jlcr.1560

Starting with [¹⁴C]-D-tyrosine, carbon-14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3R)- and (3S)-diastereomers was carried out via the 3-phenyl-2,3,10,10a-tetrahy