Synthesis of 2-(Trifluoromethyl)indoles via Domino Trifluoromethylation/Cyclization of 2-Alkynylanilines

DOI: 10.1021/acs.orglett.8b00509

Source and publish data:

Organic Letters p. 1676 - 1679 (2018)

Update date:2022-08-02

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Authors:

Ye, Yibin

Cheung, Kelvin Pak Shing

He, Lisi

Tsui, Gavin Chit

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Article abstract of DOI:10.1021/acs.orglett.8b00509

A new method for the synthesis of 2-(trifluoromethyl)indoles using easily accessible 2-alkynylanilines and a well-established fluoroform-derived CuCF₃ reagent is described. This method utilizes a domino trifluoromethylation/cyclization strategy

Full text of DOI:10.1021/acs.orglett.8b00509

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