New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties

DOI: 10.1021/jm00123a028

Source and publish data:

Journal of Medicinal Chemistry p. 663 - 671 (1989)

Update date:2022-08-04

Topics:

Authors:

Bagley Bagley

Wynn Wynn

Rudo Rudo

Doorley Doorley

Spencer Spencer

Spaulding

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Article abstract of DOI:10.1021/jm00123a028

A research program based on certain heterocyclic modifications (12-50) of the fentanyl (1) molecule has generated a novel class of opioids. In the mouse hot-place test, these compounds were weaker analgesics than 1. Two types of antagonists were observed

Full text of DOI:10.1021/jm00123a028

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