New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties

DOI: 10.1021/jm00123a028

Source and publish data:

Journal of Medicinal Chemistry p. 663 - 671 (1989)

Update date:2022-08-04

Topics:

Authors:

Bagley Bagley

Wynn Wynn

Rudo Rudo

Doorley Doorley

Spencer Spencer

Spaulding

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00123a028

A research program based on certain heterocyclic modifications (12-50) of the fentanyl (1) molecule has generated a novel class of opioids. In the mouse hot-place test, these compounds were weaker analgesics than 1. Two types of antagonists were observed

Full text of DOI:10.1021/jm00123a028

Products guided by the article

Product name:Benzo[1,2,5]thiadiazol-4-yl-(1-phenethyl-piperidin-4-ylidene)-amine

Cas No:117523-89-4

R&D Labs maybe for 117523-89-4

Taizhou Crene Biotechnology co.ltd

Contact:86-576-88813233 88205808

Address:Economic Developed Zone of Taizhou Zhejiang China
Guangzhou Reachin Chemical Co., Ltd

Contact:+86-20-37087379 ext.604

Address:A122C-1, Tianyuan Plaza, 401 Tianyuan Rd., Tianhe, Guangzhou, China
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
xujianqiang

Contact:86-21-57725962

Address:shanghai
Changzhou Screw International Trading Co., Ltd.

Contact:13906149256,18001495888

Address:Jiangsu，Jintanqu

Relevant to this article

Reaction of CH Acids with 2-Arylidenecycloalkanones: Synthesis of β-Keto Acid Anilide Derivatives of Naphthalene, Indene, Fluorene, and Phenanthrene

Doi:10.1007/BF00811862
(1994)
α-Hydroxy-Tetrazoles as Latent Ethynyl Moieties: A Mechanistic Investigation

Doi:10.1002/ejoc.201800143
(2018)
Retinoid receptor subtype-selective modulators through synthetic modifications of RARγ agonists

Doi:10.1016/j.bmc.2009.05.035
(2009)
SYNTHESIS OF SEVEN PENTA-N,O-ACETYL-PSEUDO-2-AMINO-2-DEOXY-DL-HEXOPYRANOSES

Doi:10.1016/0008-6215(88)85053-5
(1988)
GoId(I) catalysis: Selective synthesis of six- or seven-membered heterocycles from epoxy alkynes

Doi:10.1002/ejoc.200900210
(2009)
Palladium-catalyzed allylic alkylation of carbonucleophiles with allylic borates or allylic alcohols and boron oxide under neutral conditions

Doi:10.1016/0022-328X(88)80217-1
(1988)

Article Doi