Quinazoline Antifolates Inhibiting Thymidylate Synthase: Synthesis of Four Oligo(L-γ-glutamyl) Conjugates of N10-Propargyl-5,8-dideazafolic Acid and Their Enzyme Inhibition

DOI: 10.1021/jm00121a029

Source and publish data:

Journal of Medicinal Chemistry p. 160 - 165 (1989)

Update date:2022-08-02

Topics:

Authors:

Pawelczak, Krzysztof

Jones, Terence R.

Kempny, Michal

Jackman, Ann L.

Newell, David R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a029

The synthesis is described of four oligo(γ-glutamyl) conjugates of N¹⁰-propargyl-5,8-dideazafolic acid containing a total of two, three, four, and five L-glutamic acid residues.The tert-butyl group was chosen as the carboxyl protecting group in

Full text of DOI:10.1021/jm00121a029

Products guided by the article

Product name:N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamic acid trifluoroacetate salt

Cas No:117559-55-4

R&D Labs maybe for 117559-55-4

Xi'an North Information Industry Co., Ltd. Weilv Chemical Department

Contact:+86-29-88156413

Address:Jixiang Road 99 Xi'an Shaanxi Province
Nanjing Chemzam Pharmtech Co., Ltd.

Contact:+86-25-86462165,+86-13915979898

Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
KODI CHEMICAL CO., LTD

Contact:021

Address:Pudong
Xiamen Kaijia Imp & Exp Co., Ltd.

Contact:86-592-5101177

Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Zhejiang Homart Chemical & Technology Co., Ltd.(expird)

Contact:13587107601

Address:Cuijiatianpu,Quzhou, Zhejiang, China (Mainland)

Relevant to this article

Traceless solid-phase synthesis of multiple sulfonamide-containing cyclic sulfides exploiting microwave irradiation

Doi:10.1016/j.tetlet.2009.05.028
(2009)
Total synthesis of (±)-tricyclohexaprenol, a possible forerunner of sterols in the evolution of biomembranes

Doi:10.1016/S0040-4039(00)96875-8
(1987)
Exploration of the CuAAC reaction for the synthesis of novel 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines

Doi:10.1055/s-0032-1317379
(2012)
Asymmetric total synthesis of (-)-plicatic acid via a highly enantioselective and diastereoselective nucleophilic epoxidation of acyclic trisubstitued olefins

Doi:10.1021/ja9039407
(2009)
Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland

Doi:10.1021/tx020019a
(2002)
SYNTHESIS OF 4-PHENYLCOUMARINS FROM DALBERGIA VOLUBILIS AND EXOSTEMA CARIBAEUM

Doi:10.1016/0031-9422(91)83677-D
(1991)

Article Doi