Quinazoline Antifolates Inhibiting Thymidylate Synthase: Synthesis of Four Oligo(L-γ-glutamyl) Conjugates of N10-Propargyl-5,8-dideazafolic Acid and Their Enzyme Inhibition

DOI: 10.1021/jm00121a029

Source and publish data:

Journal of Medicinal Chemistry p. 160 - 165 (1989)

Update date:2022-08-02

Topics:

Authors:

Pawelczak, Krzysztof

Jones, Terence R.

Kempny, Michal

Jackman, Ann L.

Newell, David R.

et al. et al.

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Article abstract of DOI:10.1021/jm00121a029

The synthesis is described of four oligo(γ-glutamyl) conjugates of N¹⁰-propargyl-5,8-dideazafolic acid containing a total of two, three, four, and five L-glutamic acid residues.The tert-butyl group was chosen as the carboxyl protecting group in

Full text of DOI:10.1021/jm00121a029

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