Quinazoline Antifolates Inhibiting Thymidylate Synthase: Synthesis of Four Oligo(L-γ-glutamyl) Conjugates of N10-Propargyl-5,8-dideazafolic Acid and Their Enzyme Inhibition

DOI: 10.1021/jm00121a029

Source and publish data:

Journal of Medicinal Chemistry p. 160 - 165 (1989)

Update date:2022-08-02

Topics:

Authors:

Pawelczak, Krzysztof

Jones, Terence R.

Kempny, Michal

Jackman, Ann L.

Newell, David R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a029

The synthesis is described of four oligo(γ-glutamyl) conjugates of N¹⁰-propargyl-5,8-dideazafolic acid containing a total of two, three, four, and five L-glutamic acid residues.The tert-butyl group was chosen as the carboxyl protecting group in

Full text of DOI:10.1021/jm00121a029

Products guided by the article

Product name:N-prop-2-ynylamino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-glutamic acid trifluoroacetate salt

Cas No:117559-55-4

R&D Labs maybe for 117559-55-4

BIOS CHEMICALS

Contact:+33-5-34012600

Address:28 ZA des Pignès
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
H&Y International Group Ltd

Contact:+86-571-86491666

Address:SHI XIANG ROAD
chengdu firsterchem Pharmaceutical Co., Ltd.

Contact:028-66825849

Address:chengdu
Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China

Relevant to this article

Traceless solid-phase synthesis of multiple sulfonamide-containing cyclic sulfides exploiting microwave irradiation

Doi:10.1016/j.tetlet.2009.05.028
(2009)
Total synthesis of (±)-tricyclohexaprenol, a possible forerunner of sterols in the evolution of biomembranes

Doi:10.1016/S0040-4039(00)96875-8
(1987)
Exploration of the CuAAC reaction for the synthesis of novel 3-(triazol-1-yl)methyl-imidazo[1,2-a]pyridines

Doi:10.1055/s-0032-1317379
(2012)
Asymmetric total synthesis of (-)-plicatic acid via a highly enantioselective and diastereoselective nucleophilic epoxidation of acyclic trisubstitued olefins

Doi:10.1021/ja9039407
(2009)
Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland

Doi:10.1021/tx020019a
(2002)
SYNTHESIS OF 4-PHENYLCOUMARINS FROM DALBERGIA VOLUBILIS AND EXOSTEMA CARIBAEUM

Doi:10.1016/0031-9422(91)83677-D
(1991)

Article Doi