2-ARYL-1,2-DIAZETIDIN-3-ONES (AZA-β-LACTAMS) VIA GRIGNARD-INDUCED CYCLIZATION OF α-(2-ARYLHYDRAZINO)-ESTERS

DOI: 10.1016/S0040-4039(00)96917-X

Source and publish data:

Tetrahedron Letters p. 6577 - 6580 (1987)

Update date:2022-09-26

Topics:

Authors:

Schantl, Joachim G.

Decristoforo, Martin

Daly, John J.

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Article abstract of DOI:10.1016/S0040-4039(00)96917-X

The α-(2-arylhydrazino)-esters 1 react with i-propylmagnesium iodide to furnish 2-aryl-1,2-diazetidin-3-ones 2, which in turn undergo ring-opening with methyllithium affording α-(2-arylhydrazino)-ketones 3.

Full text of DOI:10.1016/S0040-4039(00)96917-X

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