2-ARYL-1,2-DIAZETIDIN-3-ONES (AZA-β-LACTAMS) VIA GRIGNARD-INDUCED CYCLIZATION OF α-(2-ARYLHYDRAZINO)-ESTERS

DOI: 10.1016/S0040-4039(00)96917-X

Source and publish data:

Tetrahedron Letters p. 6577 - 6580 (1987)

Update date:2022-09-26

Topics:

Authors:

Schantl, Joachim G.

Decristoforo, Martin

Daly, John J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)96917-X

The α-(2-arylhydrazino)-esters 1 react with i-propylmagnesium iodide to furnish 2-aryl-1,2-diazetidin-3-ones 2, which in turn undergo ring-opening with methyllithium affording α-(2-arylhydrazino)-ketones 3.

Full text of DOI:10.1016/S0040-4039(00)96917-X

Products guided by the article

Product name:2-(4-Chloro-phenyl)-4,4-dimethyl-[1,2]diazetidin-3-one

Cas No:117609-32-2

R&D Labs maybe for 117609-32-2

QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.
Foreschem Co., Ltd

Contact:+86-533-3112891

Address:zibo
Yangzhou Siyu Chemical Co.,Ltd.

Contact:+86-514-87325867 13358126196

Address:Room 620 Exposition Pavilion，No. 98 Huaihai Road,Guangling District，Yangzhou City, Jiangsu Province
Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian

Relevant to this article

The synthesis of dienecarbamates as adapt prodrug models

Doi:10.1080/00397919708004108
(1997)
Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

Doi:10.1080/14756366.2016.1244532
(2017)
ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

Doi:10.1021/jm960167w
(1996)
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P₁ or P₁'phenyl substituents: X-ray crystal structure assisted design

Doi:10.1021/jm00088a003
(1992)
SYNTHESIS AND THERMAL CHEMISTRY OF ISOLEVOGLUCOSENONE

Doi:10.1016/0008-6215(86)85029-7
(1986)
Polycarbonylmethyl Derivatives: Reactions of 2-(3-Methyl-5-isoxazolyl)-1-phenylethanone

Doi:10.1002/ardp.19863190310
(1986)

Article Doi