Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems - I. 2-alkoxymethyl derivatives

DOI: 10.1016/S0968-0896(97)00142-9

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2069 - 2087 (1997)

Update date:2022-08-05

Topics: Synthesis Antibacterial activity

Authors:

Azami, Hidenori

Tsutsumi, Hideo

Matsuda, Keiji

Barrett, David

Hattori, Kouji

Nakajima, Takashi

Kuroda, Satoru

Kamimura, Toshiaki

Murata, Masayoshi

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Article abstract of DOI:10.1016/S0968-0896(97)00142-9

The synthesis and in vitro antibacterial activity of a novel series of 2-alkoxymethyl-4-pyrrolidinylthio-1β-methyl carbapenems are described. As a result of these studies, we discovered that FR27743 (19j) containing a novel 2-fluoroethoxymethyl substituen

Full text of DOI:10.1016/S0968-0896(97)00142-9

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Product name:(2S,4R)-1-benzyloxycarbonyl-2-(ethoxycarbonylmethyl)oxymethyl-4-methanesulfonyloxypyrrolidine

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