Daphniphyllum Alkaloids. 11. Biomimetic Total Synthesis of Methyl Homosecodaphniphyllate. Development of the Tetracyclization Reaction

DOI: 10.1021/jo00035a008

Source and publish data:

Journal of Organic Chemistry p. 2544 - 2553 (1992)

Update date:2022-07-30

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Authors:

Heathcock, Clayton H.

Hansen, Marvin M.

Ruggeri, Roger B.

Kath, John C.

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Article abstract of DOI:10.1021/jo00035a008

A biomimetic total synthesis of (+/-)-methyl homosecodaphniphyllate has been developed.The synthesis starts with a triply convergent, tandem Michael addition-enolate alkylation, wherein amide 9, enoate 7, and alkyl iodide 5 are assembled in essentially qu

Full text of DOI:10.1021/jo00035a008

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