REGIO- AND CHEMOSELECTIVE ADDITION OF ALKYNYLTIN REAGENTS TO THE 2-POSITION OF 3-ACYLPYRIDINES ACTIVATED BY METHYL CHLOROFORMATE: SELECTIVE SYNTHESIS OF 2,3-DISUBSTITUTED 1,2-DIHYDROPYRIDINES

DOI: 10.1016/S0040-4039(00)82043-2

Source and publish data:

Tetrahedron Letters p. 1785 - 1788 (1988)

Update date:2022-08-05

Topics:

Authors:

Yamaguchi, Ryohei

Hata, Ei-ichiro

Utimoto, Kiitiro

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)82043-2

Alkynyltin reagents add to the 2-position of 3-acylpyridines activated by methyl chloroformate regio- and chemoselectively to give 2,3-disubstituted 1,2-dihydropyridines, whereas alkynyl Grignard reagents suffer from a lack of regio- or chemoselectivity.

Full text of DOI:10.1016/S0040-4039(00)82043-2

Products guided by the article

Product name:5-Acetyl-2-(4-benzyloxy-but-1-ynyl)-2H-pyridine-1-carboxylic acid methyl ester

Cas No:118160-91-1

R&D Labs maybe for 118160-91-1

QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.
SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
X.T.Y Environ-Tech Co.,Ltd

Contact:+86-310-7092106

Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone

Relevant to this article

Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate

Doi:10.1124/dmd.111.044446
(2012)
Highly enantioselective Rh-catalyzed hydrogenation of β,γ- unsaturated phosphonates with chiral ferrocene-based monophosphoramidite ligands

Doi:10.1021/jo901619c
(2009)
Lewis Acid Mediated Nucleophilic Substitution Reactions of 2-Alkoxy-3,4-dihydro-2H-1-benzopyrans: Regiochemistry and Utility in the Synthesis of 3,4-Dihydro-2H-1-benzopyran-2-carboxylic Acids

Doi:10.1021/jo00275a010
(1989)
Oxidation of vitamin E: Evidence for competing autoxidation and peroxyl radical trapping reactions of the tocopheroxyl radical

Doi:10.1021/ja00175a037
(1990)
1,3-Dipolar Cycloaddition of Nitrones with Nitriles. Scope and Mechanistic Study

Doi:10.1016/S0040-4020(01)89838-0
(1988)
Bis(μ₂-1-carboxybenzene-2-carboxylato)diaqua(monohydrogen phthalato)-(1,10-phenanthroline)samarium(III): Hydrothermal synthesis and crystal structure

Doi:10.1134/S1070328409110128
(2009)

Article Doi