REGIO- AND CHEMOSELECTIVE ADDITION OF ALKYNYLTIN REAGENTS TO THE 2-POSITION OF 3-ACYLPYRIDINES ACTIVATED BY METHYL CHLOROFORMATE: SELECTIVE SYNTHESIS OF 2,3-DISUBSTITUTED 1,2-DIHYDROPYRIDINES

DOI: 10.1016/S0040-4039(00)82043-2

Source and publish data:

Tetrahedron Letters p. 1785 - 1788 (1988)

Update date:2022-08-05

Topics:

Authors:

Yamaguchi, Ryohei

Hata, Ei-ichiro

Utimoto, Kiitiro

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Article abstract of DOI:10.1016/S0040-4039(00)82043-2

Alkynyltin reagents add to the 2-position of 3-acylpyridines activated by methyl chloroformate regio- and chemoselectively to give 2,3-disubstituted 1,2-dihydropyridines, whereas alkynyl Grignard reagents suffer from a lack of regio- or chemoselectivity.

Full text of DOI:10.1016/S0040-4039(00)82043-2

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