CYCLIZATIONS OF 1,2,4-TRIAZINIUM SALTS WITH BIFUNCTIONAL NUCLEOPHILES - A NEW ROUTE TO CONDENSED 1,2,4-TRIAZINES

Article abstract of DOI:10.1016/S0040-4039(00)80316-0

The reaction of 1,2,4-triazinium salts with amides of acetoacetic acid yielding 1,4,4a,5,7,7a-hexahydro-6H-pyrrolo<3,2-e>-1,2,4-triazin-6-ones exemplifies the first direct annelation to the 1,2,4-triazine ring based on the diaddition of bifunctional nucleophiles at C-5 and C-6.