Facing the gem-dialkyl effect in enzyme inhibitor design: Preparation of homocycloleucine-based azadipeptide nitriles

DOI: 10.1002/chem.201101350

Source and publish data:

Chemistry - A European Journal p. 11419 - 11423 (2011)

Update date:2022-08-04

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Authors:

Frizler, Maxim

Lohr, Friederike

Luelsdorff, Michael

Guetschow, Michael

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Article abstract of DOI:10.1002/chem.201101350

A tough nut to crack: In contrast to azadipeptide nitriles containing a P2 leucine residue, the synthesis of the corresponding homocycloleucine-based inhibitors was more difficult; possibly due to the gem-dialkyl effect. A synthetic route to the first hom

Full text of DOI:10.1002/chem.201101350

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