Organic and Biomolecular Chemistry p. 2341 - 2344 (2017)
Update date:2022-07-30
Topics:
Fu, Haigen
Younes, Sabry H. H.
Saifuddin, Mohammad
Tepper, Pieter G.
Zhang, Jielin
Keller, Erik
Heeres, André
Szymanski, Wiktor
Poelarends, Gerrit J.
The complex amino acid (l-threo)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (l-TFB-TBOA) and its derivatives are privileged compounds for studying the roles of excitatory amino acid transporters (EAATs) in regulation of glutamatergic neurotransmission, animal behavior, and in the pathogenesis of neurological diseases. The wide-spread use of l-TFB-TBOA stems from its high potency of EAAT inhibition and the lack of off-target binding to glutamate receptors. However, one of the main challenges in the evaluation of l-TFB-TBOA and its derivatives is the laborious synthesis of these compounds in stereoisomerically pure form. Here, we report an efficient and step-economic chemoenzymatic route that gives access to enantio- and diastereopure l-TFB-TBOA and its derivatives at multigram scale.
View MoreTianjin Hedong Red Cliff Chemical Reagent Factory
Contact:+86-022-84780548
Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
Contact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Contact:86-25-84683399
Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Contact:+86-574- 87178138; 87297407
Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
LIAOYANG TENGYUAN FOOD ADDITIVE FACTORY
Contact:+86-419-5807666
Address:Haodianzi village,Hanling Town,Liaoyang county
Doi:10.1021/jo00267a008
(1989)Doi:10.1016/j.bmcl.2008.01.112
(2008)Doi:10.1515/znb-2008-0216
(2008)Doi:10.1021/jo00362a018
(1986)Doi:10.1021/ja048655d
(2004)Doi:10.1016/j.ejmech.2005.04.016
(2005)