SYNTHESIS OF PHENOXYPYRIDINES UNDER PHASE TRANSFER CATALYSIS CONDITIONS

Article abstract of DOI:10.1007/BF00475326

Reactions of halopyridines with alkali metal phenoxides in a two phase liquid-solid catalytic system, rather than in a liquid-liquid phase transfer catalytic system, make it possible to prepare 2-, 3-, and 4-phenoxypyridines from unactivated bromo- or chloropyridines and 2-chloropicolines.In polyhalogenated pyridines only α- and γ-halogen atoms undergo substitution. 7,8-Dibromo-6-azaphenoxane has been prepared by the reaction of 2,3,5,6-tetrabromopyridine with the dipotassium salt of pyrocatechol.