Asymmetric synthesis and σ receptor affinity of enantiomerically pure 1,4-disubstituted tetrahydro-1H-3-benzazepines

DOI: 10.1016/j.tetasy.2009.05.017

Source and publish data:

Tetrahedron Asymmetry p. 1383 - 1392 (2009)

Update date:2022-07-30

Topics:

Authors:

Husain, Syed Masood

Heim, Marie Theres

Schepmann, Dirk

Wuensch, Bernhard

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Article abstract of DOI:10.1016/j.tetasy.2009.05.017

A very short (three steps) asymmetric synthesis of enantiomerically pure 1,4-disubstituted tetrahydro-1H-3-benzazepines 14 has been elaborated upon, starting from the trans- and cis-configured 11a-substituted 3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3

Full text of DOI:10.1016/j.tetasy.2009.05.017

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Product name:(3R,6S,11aR)-6-benzyl-11a-butyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo [2,3-b]-[3]-benzazepin-5(6H)-one

Cas No:1186339-77-4

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