ALKYLATION DU TRIFLUOROACETYLACETATE D'ETHYLE METHODE GENERALE D'ACCES AUX TRIFLUOROMETHYLCETONES. 2eme PARTIE: ALKYLATIONS INDIRECTS DU TFAAE

Article abstract of DOI:10.1016/S0022-1139(00)82804-3

A versatile method of alkylation of ethyltrifluoroacetylacetate (ETFAA) allowed selective C-alkylation of ETFAA, whatever the structure of alkyl halide was, providing that the carbonyl function was masked into a dioxolan 3 or a N,N-dimethyl hydrazone 5.These last derivatives were easily alkylated and their specific deprotection led to various C-alkylated ETFAA which in turn allowed, by a simple decarbethoxylation, the preparation of the corresponding trifluoromethyl ketones in good yields.