DESIGN AND SYNTHESIS OF CATHEPSIN B INHIBITORS BY AN AFFINITY LABELING APPROACH

Article abstract of DOI:10.1246/cl.1988.1857

The affinity labeling approach by the use of S-(3-nitro-2-pyridinesulfenyl) group was demonsrated to be effective and versatile to the design and synthesis of thiol protease inhibitors.The inhibitors were found to be highly specific to thiol proteases and