Bioorganic and Medicinal Chemistry Letters p. 4542 - 4545 (2009)
Update date:2022-07-31
Topics:
Wang, Xiaofang
Creek, Darren J.
Schiaffo, Charles E.
Dong, Yuxiang
Chollet, Jacques
Scheurer, Christian
Wittlin, Sergio
Charman, Susan A.
Dussault, Patrick H.
Wood, James K.
Vennerstrom, Jonathan L.
These data suggest that iron(II) reactivity for a set of homologous spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane peroxide heterocycles is a necessary, but insufficient, property of animalarial peroxides. Heme alkylation efficiency appears to give a more accurate prediction of antimalarial activity than FeSO4-mediated reaction rates, suggesting that antimalarial activity is not merely dependent on peroxide bond cleavage, but also on the ability of reactive intermediates to alkylate heme or other proximal targets.
View MoreZhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
Hangzhou Eastbiopharm Co.,Ltd.
Contact:+86-571-88931780
Address:Hangzhou,China
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address: Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Changsha Goomoo Chemical Technology Co.Ltd
Contact:+86-731-82197655
Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Disynthesis Chemical Technology Co. Ltd.
Contact:+86-571-88194596
Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Doi:10.1134/S1070428009020158
(2009)Doi:10.1002/jhet.70
(2009)Doi:10.1021/jm00106a045
(1991)Doi:10.1002/anie.200902078
()Doi:10.1002/anie.200902015
(2009)Doi:10.1039/c6sc03109a
(2016)