Bioorganic and Medicinal Chemistry Letters p. 4542 - 4545 (2009)
Update date:2022-07-31
Topics:
Wang, Xiaofang
Creek, Darren J.
Schiaffo, Charles E.
Dong, Yuxiang
Chollet, Jacques
Scheurer, Christian
Wittlin, Sergio
Charman, Susan A.
Dussault, Patrick H.
Wood, James K.
Vennerstrom, Jonathan L.
These data suggest that iron(II) reactivity for a set of homologous spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane peroxide heterocycles is a necessary, but insufficient, property of animalarial peroxides. Heme alkylation efficiency appears to give a more accurate prediction of antimalarial activity than FeSO4-mediated reaction rates, suggesting that antimalarial activity is not merely dependent on peroxide bond cleavage, but also on the ability of reactive intermediates to alkylate heme or other proximal targets.
View MoreSuzhou Sinosun Imp.&Exp. Corporation
website:http://www.szsinosun.com
Contact:+86-512-63488895,63488616
Address:No.758 East Jiangling Road Wujiang Economic & Technological Developmenty Zone Jiangsu China
Contact:0086-29-89196322
Address:North of the Fifth Keji Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
Contact:+86-21-61318535
Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
website:http://www.debyesci.com
Contact:+85221376140
Address:Rm. 19C, Lockhart Ctr., 301-307 Lockhart Rd., Wan Chai
Doi:10.1134/S1070428009020158
(2009)Doi:10.1002/jhet.70
(2009)Doi:10.1021/jm00106a045
(1991)Doi:10.1002/anie.200902078
()Doi:10.1002/anie.200902015
(2009)Doi:10.1039/c6sc03109a
(2016)