
Tetrahedron Letters p. 3057 - 3060 (1988)
Update date:2022-08-02
Topics:
Schmidt, U.
Kroner, M.
Griesser, H.
The 23-membered peptolide ring of the didemnins is formed in a two phase cyclization of a linear ω-amino-pentafluorophenyl ester in 70percent yield without high dilution. (2RS,4S)-2,5-dimethyl-4-hydroxy-3-oxohexanoic acid (Hip) and (3S,4R,5S)-isostatine are synthesized by acylations of trimethylsilyl malonates.
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