Journal of Organic Chemistry p. 1736 - 1743 (1989)
Update date:2022-08-02
Topics:
Warshaw, James A.
Gallis, David E.
Acken, Bruce J.
Gonzalez, Orestes J.
Crist, DeLanson R.
A general method was developed for the synthesis of acyclic α-alkoxynitrones (imidate N-oxides), a relatively new class of compounds.Regioselective alkylation of hydroxamic acids under neutral conditions with alkyl trifluoromethanesulfonates (triflates) gave nitrone hydrotriflates, and deprotonation by one of three methods gave the rather unstable nitrones in overall yields from 4 to 85percent.A wide range of substitution was possible, with R = H, Me, or Ar, R1 = Me or t-Bu, and R2 = Me or Et.The reactivity of these nitrones toward examples
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Contact:86-574-26865651
Address:529 YuanBaoShan Road, Beilun District
website:http://www.u-chemo.com
Contact:+86-21-61558312
Address:Dong Fang Road,
Wuxi Forest Biological Co.,Ltd
Contact:+86-510-81602300
Address:Room 317,Building D, No.159 middle Chengjiang Road,Jiangyin Wuxi city.
ShangHai Original Economy-Trade Develop Co.,Ltd.,
Contact:86-21-68552131
Address:shanghai
Doi:10.1016/j.tetlet.2015.08.058
(2015)Doi:10.1016/j.tet.2020.131353
(2020)Doi:10.1039/b910486k
(2009)Doi:10.3762/bjoc.15.62
(2019)Doi:10.1002/anie.200901647
()Doi:10.1021/acs.orglett.1c00468
(2021)