Efficient synthesis of 2-substituted pyrido[3,2-d]pyrimidines involving SNAr and palladium-catalyzed cross-coupling reactions

Article abstract of DOI:10.1055/s-0029-1216854

The efficient and original synthesis of various 2-substituted pyrido[3,2-d]pyrimidines is reported. Starting from 2,4-dichloropyrido [3,2-d]pyrimidine, a regioselective pallado-dehalogenation led to 2-chloropyrido[3,2-d]pyrimidine, which was used in SNAr and palladium-catalyzed cross-coupling reactions in order to afford highly functionalized products in very good yields. Georg Thieme Verlag Stuttgart.