TiCl4 Induced Opening of Chiral Acetals: a route to β-adrenergic blocking agents

Article abstract of DOI:10.1016/0040-4039(88)85056-1

Aryloxy and alkyloxypropanolamines 7a-c are obtained in 45 to 70 percent yields and with asymmetric induction, using TiCl4 induced nucleophilic addition of cyanotrimethylsilane onto chiral acetals derived from racemic 2,4-pentanediol.Therefore, optically pure 2,4-pentanediol will provide, after a purification, optically pure 7a-c.