Chemistry of Heterocyclic Compounds p. 514 - 518 (1988)
Update date:2022-07-29
Topics: Synthesis Derivatives Nucleosides Experimental terms Acyclic Trifluoromethyl Benzimidazole Hydroxyalkyl
Yavorskii, A. E.
Stetsenko, A. V.
Gogoman, I. V.
Boiko, V. N.
Zavgorodnii, S. G.
et al.
1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthiobenzimidazoles were obtained by condensation of trimethylsilyl derivatives of 2-substituted benzimidazoles with alkylating agents in the presence of SnCl4 or by direct alkylation of the sodium salts of the heterocycles.
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Doi:10.1021/ja9077446
(2009)Doi:10.1016/j.bmcl.2009.08.043
(2009)Doi:10.1016/S0040-4039(00)82122-X
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(1988)Doi:10.1016/j.bmc.2010.07.048
(2010)
