Synthetic utility of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane): the reaction between HCFC-123 and aldehydes using zinc

Article abstract of DOI:10.1016/0022-1139(94)03141-L

HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) reacted with zinc and aldehydes to afford predominantly either 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols or 1-substituted 2,2-dichloro-3,3,3-trifluoro-1-propanols.The reactions proceeded via 1,1-dichloro-2,2,2-trifluoroethylzinc chloride as an organozinc intermediate. - Keywords: 2,2-Dichloro-1,1,1-trifluoroethane; Reaction; Aldehydes; Zinc; 1,1-Dichloro-2,2,2-trifluoroethylzinc chloride