Stereoselective Reduction of Bicyclic Ketals. An Efficient Synthesis of (-)-(R,R)-(cis-6-Methyltetrahydropyran-2-yl)-acetic Acid, an Enantiomer of Civet Cat Constituent

Article abstract of DOI:10.1246/cl.1988.927

(-)-(R,R)-(cis-6-Methyltetrahydropyran-2-yl)acetic acid, an enantiomer of civet cat constituent, was prepared in high yield by using a stereoselective reduction of bicyclic ketals as a key step.