
Tetrahedron Letters p. 4143 - 4146 (1988)
Update date:2022-09-26
Topics:
Wada, Takeshi
Hotoda, Hitoshi
Sekine, Mitsuo
Hata, Tsujiaki
Various disubstituted phosphonates including alkylnucleoside 3'-phosphonates were converted rapidly into the corresponding phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) as a chlorinating reagent.The reaction was found to be applicable to the rapid and practical synthesis of oligonucleotides.
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