2-CYANOETHYL NUCLEOSIDE 3'-PHOSPHONATES AS NOVEL STARTING MATERIALS FOR OLIGONUCLEOTIDE SYNTHESIS

Article abstract of DOI:10.1016/S0040-4039(00)80439-6

Various disubstituted phosphonates including alkylnucleoside 3'-phosphonates were converted rapidly into the corresponding phosphorochloridites by use of tris(2,4,6-tribromophenoxy)dichlorophosphorane (BDCP) as a chlorinating reagent.The reaction was found to be applicable to the rapid and practical synthesis of oligonucleotides.