Identification of a Potent and Selective 5-HT6 Antagonist: One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(Benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile

DOI: 10.1021/jm034142q

Source and publish data:

Journal of Medicinal Chemistry p. 4834 - 4837 (2003)

Update date:2022-09-26

Topics:

Authors:

Wu, Yong-Jin

He, Huan

Hu, Shuanghua

Huang, Yazhong

Scola, Paul M.

Grant-Young, Katharine

Bertekap, Robert L.

Wu, Dedong

Gao, Qi Gao, Qi

Li, Yi Li, Yi

Klakouski, Cheryl

Westphal, Ryan S.

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Article abstract of DOI:10.1021/jm034142q

(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido-[1,2-a] pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT ₆ antagonist. A one-step synthesis of this compound is described.

Full text of DOI:10.1021/jm034142q

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Product name:2-(benzenesulfonyl)-3-methoxyacrylonitrile

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