Asymmetric Michael addition reaction of 3-substituted oxindoles to nitroolefins catalyzed by a chiral alkyl-substituted thiourea catalyst

Article abstract of DOI:10.1002/adsc.200900630

A simple alkylthiourea was found to be an effective catalyst for the Michael addition reaction of 3-substituted oxindole to nitroolefins. A number of 3,3′-substituted oxindole derivatives, which have two vicinal quaternary-tertiary chiral centers were syn