Journal of Medicinal Chemistry p. 1118 - 1127 (1989)
Update date:2022-07-30
Topics:
Kaminski
Solomon
Conn
Wong
Chiu
Massa
Siegel
Watnick
A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi
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