Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones

DOI: 10.1021/jm00125a029

Source and publish data:

Journal of Medicinal Chemistry p. 1118 - 1127 (1989)

Update date:2022-07-30

Topics:

Authors:

Kaminski

Solomon Solomon

Conn Conn

Wong Wong

Chiu Chiu

Massa Massa

Siegel Siegel

Watnick Watnick

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00125a029

A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi

Full text of DOI:10.1021/jm00125a029

Products guided by the article

Product name:1,3-Dimethyl-9-<(4-methoxyphenyl)methyl>-6-hydroxypyrimido<2,1-f>purine-2,4,8(1H,3H,9H)-trione

Cas No:120144-42-5

R&D Labs maybe for 120144-42-5

Zhenjiang Haitong Chemical Industry Co., Ltd.

Contact:+86 (511) 8448-0369

Address:Baoyan Town, Dantu District, Zhenjiang City, Jiangsu, China
Shanghai HengXun Pharmaceutical Tech. Co., Ltd.

Contact:86-86-52730756

Address:Room 603, No. 240, Tianmuzhong Road, Zhabei, Shanghai, China
Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK
Zhejiang Newfine Industry Co.,Ltd.

Contact:+86-573-82262042

Address:No.225,Dongqing Road, garoms@163.com

Relevant to this article

Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile

Doi:10.1016/j.bmc.2018.04.051
(2018)
A Short Synthesis of a Pyrrole Derivative Having a Chiral Substituent

Doi:10.1055/s-1988-27697
(1988)
Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90

Doi:10.1021/jm201155e
(2011)
ANOMALOUS RING OPENING OF N-ARYL-2-OXAZOLIDINONES BY ANHYDROUS ALKOXIDE:A CONVENIENT PREPARATION OF N-(ALKOXYETHYL)-2,6-DISUBSTITUTED ANILINES

Doi:10.1016/S0040-4039(00)80688-7
(1988)
Formation of 2-(2-furoyl)-4(5)-(2-furyl)-1H-imidazole in the Maillard reaction

Doi:10.1016/0008-6215(88)84012-6
(1988)
Enantioselective one-pot organocatalytic michael addition/goldcatalyzed tandem acetalization/cyclization

Doi:10.1002/anie.200903905
(2009)

Article Doi