Antiinflammatory activity of a series of substituted 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-diones

DOI: 10.1021/jm00125a029

Source and publish data:

Journal of Medicinal Chemistry p. 1118 - 1127 (1989)

Update date:2022-07-30

Topics:

Authors:

Kaminski

Solomon Solomon

Conn Conn

Wong Wong

Chiu Chiu

Massa Massa

Siegel Siegel

Watnick Watnick

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Article abstract of DOI:10.1021/jm00125a029

A series of substituted analogues based on the novel 2,3-dihydro-6-hydroxypyrimido[2,1-f]purine-4,8(1H,9H)-dione ring system have been synthesized and shown to exhibit antiinflammatory activity in the adjuvant-induced arthritis rat model (AAR). The activi

Full text of DOI:10.1021/jm00125a029

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