Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds

DOI: 10.1021/jm00126a023

Source and publish data:

Journal of Medicinal Chemistry p. 1284 - 1289 (1989)

Update date:2022-09-26

Topics:

Authors:

Patil Patil

Jones Jones

Nair Nair

Galivan Galivan

Maley Maley

Kisliuk Kisliuk

Gaumont Gaumont

Duch Duch

Ferone Ferone

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00126a023

The chemical synthesis of three close analogues (2-4) of N¹⁰-propargyl-5,8-dideazafolate (PDDF) is described. The quinazoline ring of 2 and 4 was constructed from the pivotal intermediate 9 in a novel and unambiguous manner during the final ste

Full text of DOI:10.1021/jm00126a023

Products guided by the article

Product name:(S)-2-{4-[(4-Oxo-2-trifluoromethyl-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

Cas No:119820-60-9

R&D Labs maybe for 119820-60-9

Hubei Sibo Technology Co.,Ltd.

Contact:0715-6597222

Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Hangzhou Hysen Pharma co.,Ltd.

website:http://www.hysenpharma.cn/

Contact:0086-571-88298791

Address:#701,Gudun Road Hangzhou
JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
Jinan Trio PharmaTech Co., Ltd

Contact:86-531-88811783；+(0)13153010282

Address:2766 Yingxiu Road, Jinan High-Tech Zone, China
uni source industries limited

Contact:86 21 3772 9386

Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China

Relevant to this article

Indium triflate-catalyzed one-pot synthesis of 14-alkyl or aryl-14h-dibenzo[a,j]xanthenes in water

Doi:10.1002/hc.20539
(2009)
The development of a new manufacturing route to the novel anticonvulsant, SB-406725A

Doi:10.1021/op9002054
(2010)
Tandem one-pot CO₂ reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

Doi:10.1039/c8cc06820h
(2018)
Stereoselective Alkylation of Glycine Units in Dipeptide Derivatives: "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center

Doi:10.1021/ja00189a042
(1989)
Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1-(4- substituted/unsubstituted benzylidene) semicarbazide: Novel agents with analgesic, anti-inflammatory and ulcerogenic properties

Doi:10.1016/j.cclet.2012.03.014
(2012)
Stereoselective synthesis of bromopiperidinones and their conversion to annulated heterocycles

Doi:10.1515/znb-2009-11-1251
(2009)

Article Doi