Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds

DOI: 10.1021/jm00126a023

Source and publish data:

Journal of Medicinal Chemistry p. 1284 - 1289 (1989)

Update date:2022-09-26

Topics:

Authors:

Patil Patil

Jones Jones

Nair Nair

Galivan Galivan

Maley Maley

Kisliuk Kisliuk

Gaumont Gaumont

Duch Duch

Ferone Ferone

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00126a023

The chemical synthesis of three close analogues (2-4) of N¹⁰-propargyl-5,8-dideazafolate (PDDF) is described. The quinazoline ring of 2 and 4 was constructed from the pivotal intermediate 9 in a novel and unambiguous manner during the final ste

Full text of DOI:10.1021/jm00126a023

Products guided by the article

Product name:(S)-2-{4-[(4-Oxo-2-trifluoromethyl-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid diethyl ester

Cas No:119820-60-9

R&D Labs maybe for 119820-60-9

Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Henan zhongda Biological Engineering Co., Ltd

Contact:86-28-18109029985

Address:shenzhou road,xuedian industrial estate,zhengzhou city,henan province CHN
AllyChem Co., Ltd., Dalian, China（BBChem）

Contact:+86-411-62313318/62313328

Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
Hebei Kangtai Pharmaceutical Co.,Ltd

Contact:+86-0317-3512963

Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China

Relevant to this article

Indium triflate-catalyzed one-pot synthesis of 14-alkyl or aryl-14h-dibenzo[a,j]xanthenes in water

Doi:10.1002/hc.20539
(2009)
The development of a new manufacturing route to the novel anticonvulsant, SB-406725A

Doi:10.1021/op9002054
(2010)
Tandem one-pot CO₂ reduction by PMHS and silyloxycarbonylation of aryl/vinyl halides to access carboxylic acids

Doi:10.1039/c8cc06820h
(2018)
Stereoselective Alkylation of Glycine Units in Dipeptide Derivatives: "Chirality Transfer" via a Pivalaldehyde N,N-Acetal Center

Doi:10.1021/ja00189a042
(1989)
Design and synthesis of 4-(1-(4-chlorobenzyl)-2,3-dioxoindolin-5-yl)-1-(4- substituted/unsubstituted benzylidene) semicarbazide: Novel agents with analgesic, anti-inflammatory and ulcerogenic properties

Doi:10.1016/j.cclet.2012.03.014
(2012)
Stereoselective synthesis of bromopiperidinones and their conversion to annulated heterocycles

Doi:10.1515/znb-2009-11-1251
(2009)

Article Doi