Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds

DOI: 10.1021/jm00126a023

Source and publish data:

Journal of Medicinal Chemistry p. 1284 - 1289 (1989)

Update date:2022-09-26

Topics:

Authors:

Patil Patil

Jones Jones

Nair Nair

Galivan Galivan

Maley Maley

Kisliuk Kisliuk

Gaumont Gaumont

Duch Duch

Ferone Ferone

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Article abstract of DOI:10.1021/jm00126a023

The chemical synthesis of three close analogues (2-4) of N¹⁰-propargyl-5,8-dideazafolate (PDDF) is described. The quinazoline ring of 2 and 4 was constructed from the pivotal intermediate 9 in a novel and unambiguous manner during the final ste

Full text of DOI:10.1021/jm00126a023

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