N-PHENOXYACETYLATED GUANOSINE AND ADENOSINE PHOSPHORAMIDITES IN THE SOLID PHASE SYNTHESIS OF OLIGORIBONUCLEOTIDES: SYNTHESIS OF A RIBOZYME SEQUENCE

Article abstract of DOI:10.1016/S0040-4039(00)80466-9

Phosphoramidites for guanosine and adenosine nucleosides with phenoxyacetyl as N-acyl protecting group were prepared.These nucleoside phosphoramidites, together with previously reported uridine and N-benzoyl cytidine phosphoramidites have been applied to the efficient solid phase synthesis of a trideca and a nonadecaribonucleotide.The later molecule has the sequence corresponding to a ribozyme.