Bioorganic and medicinal chemistry letters p. 261 - 264 (1999)
Update date:2022-07-30
Topics:
Kley
von Kiedrowski
Unger
Massing
Acylamino inhibitors of 14 kDa-PLA2 were synthesized which differ in the moiety that is not bound into the enzyme's active site but immersed in the lipid aggregate when a ternary inhibitory complex is formed. Our results indicate that this part of the inhibitors does not significantly influence inhibitory properties as long the amphiphilic character is retained. So, inhibitory and biophysical properties should be variable independently.
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