3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase

DOI: 10.1021/jm00082a002

Source and publish data:

Journal of Medicinal Chemistry p. 620 - 628 (1992)

Update date:2022-09-26

Topics:

Authors:

Martinez

Walker Walker

Hirschfeld

Bruno Bruno

Yang Yang

Maloney Maloney

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Article abstract of DOI:10.1021/jm00082a002

A series of 1H-imidazol-1-yl- and 3-pyridyl-substituted 3,4- dihydroquinolin-2(1H)-ones was designed and synthesized as combined inhibitors of thromboxane (TXA₂) synthase and cAMP phosphodiesterase (PDE) in human blood platelets. A number of st

Full text of DOI:10.1021/jm00082a002

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