
Tetrahedron p. 4619 - 4630 (1988)
Update date:2022-08-05
Topics:
Sapi, Janos
Szabo, Lajos
Baitz-Gacs, Eszter
Kalaus, Gyoergy
Szantay, Csaba
The α-oxo-acids 4 and 5 derived from vincamone (1) were transformed into vincamines 2,9,10, respectively by methylene insertion with diazomethane.Homologization of 3 and 6 dioxo compounds led to oxirane derivatives 8,16,11,13, 18, respectively.Configuration of the oxiranes was determined by (1)H-NOE measurements.
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