Journal of Medicinal Chemistry p. 1517 - 1522 (1989)
Update date:2022-08-04
Topics:
Taylor, Edward C.
Hamby, James M.
Shih, Chuan
Grindey, Gerald B.
Rinzel, Sharon M.
et al.
Syntheses of 5-deaza-5,6,7,8-tetrahydrofolic acid (7a) and its 10-formyl (7b), 10-acetyl (7c), and 10-methyl (7d) derivatives are described.These compounds, prepared as analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), the lead compound of
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