Asymmetric Reduction of α-(Dimethylthiocarbamoylthio) Carbonyl Compounds with Bakers' Yeast

Article abstract of DOI:10.1246/bcsj.61.3205

Treatment of α-(dimethythiocarbamoylthio) ketones with bakers' yeast afforded the corresponding chiral alcohols in high yields with high enentiomeric excess (in most cases, more than 96 percent ee). α- (Dimethylthiocarbamoylthio) aldehydes were reduced to give chiral α-(dimethylthiocarbamoylthio) alcohols in 69-92 percent yields with 32-63 percent ee, which were converted to chiral 1,2-epitio derivatives.