Tetrahedron Letters (2020)
Update date:2022-08-03
Topics:
Bao, Xuefei
Chang, Yan
Chen, Guoliang
He, Xiaoyan
Liu, Zi'ao
Lu, Xiuhong
4-((1H-benzo[d]imidazol-2-yl)oxy)-3-methylpicolinic acid (11) is a key related substance of Rabeprazole sodium. In this article, this key related substance is synthesized by using 3-methylpicolinonitrile as a starting material via a five-step processes. By converting 3-methylpicolinonitrile to 4-hydroxy-3-methylpicolinonitrile (13), the preparation of TM becomes practical. This work provides a guarantee for quality standard establishment of Rabeprazole sodium.
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Doi:10.1002/ejoc.200900871
(2009)Doi:10.1002/zaac.200800382
(2009)Doi:10.1002/ejoc.200900730
(2009)Doi:10.1039/c8cc06663a
(2018)Doi:10.1007/BF00479353
(1988)Doi:10.1016/S0040-4039(00)80523-7
(1988)