Tetrahedron Letters (2020)
Update date:2022-08-03
Topics:
Bao, Xuefei
Chang, Yan
Chen, Guoliang
He, Xiaoyan
Liu, Zi'ao
Lu, Xiuhong
4-((1H-benzo[d]imidazol-2-yl)oxy)-3-methylpicolinic acid (11) is a key related substance of Rabeprazole sodium. In this article, this key related substance is synthesized by using 3-methylpicolinonitrile as a starting material via a five-step processes. By converting 3-methylpicolinonitrile to 4-hydroxy-3-methylpicolinonitrile (13), the preparation of TM becomes practical. This work provides a guarantee for quality standard establishment of Rabeprazole sodium.
View MoreChangzhou Litong Chemical Co., Ltd.
website:http://www.litonchem.com/
Contact:+86-519-86301238
Address:Laoba Rd, Hutang town Changzhou Jiangsu
Yangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Changzhou Anyi Biochem Co., Ltd.(expird)
Contact:+86-519-88836158
Address:no,51 caoda
HENAN NEW BLUE CHEMICAL CO.,LTD
website:http://www.newbluechem.com
Contact:86-371-55170693/55170694
Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Shanghai Bosman Industrial Co., Ltd
Contact:86-21-63065878-8006
Address:Rm907, No.1611, North Sichuan Road, Hongkou District, Shanghai, 200080 China
Doi:10.1002/ejoc.200900871
(2009)Doi:10.1002/zaac.200800382
(2009)Doi:10.1002/ejoc.200900730
(2009)Doi:10.1039/c8cc06663a
(2018)Doi:10.1007/BF00479353
(1988)Doi:10.1016/S0040-4039(00)80523-7
(1988)