ACS Medicinal Chemistry Letters p. 762 - 767 (2013)
Update date:2022-08-05
Topics:
Moore, Terry W.
Sana, Kasinath
Yan, Dan
Krumm, Stefanie A.
Thepchatri, Pahk
Snyder, James P.
Marengo, Jose
Arrendale, Richard F.
Prussia, Andrew J.
Natchus, Michael G.
Liotta, Dennis C.
Plemper, Richard K.
Sun, Aiming
Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors (2 and 3) with broad-spectrum antiviral activity against ortho- and paramyxoviruses including influenza A virus (IAV), measles virus (MeV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Hit-to-lead optimization delivered inhibitor 28a, with EC50 values of 0.88 and 0.81 μM against IAV strain WSN and MeV strain Edmonston, respectively. It was also found that compound 28a delivers good stability in human liver S9 fractions with a half-life of 165 min. These data establish 28a as a promising lead for antiviral therapy through a host-directed mechanism.
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