Arkivoc p. 56 - 66 (2020)
Update date:2022-08-05
Topics:
Fisher, Louise M.
Kim, Eliana E.
Moskalev, Nicolai V.
Gribble, Gordon W.
We describe asymmetric syntheses of the potential anti-malarial drugs (S)-2-(8-fluoro-2-methyloctyl)-3-hydroxynaphthalene-1,4-dione, (S)-2-hydroxy-3-(8-trifluoromethyl-2-methyloctyl)-3-hydroxynaphthalene-1,4-dione, and (S)-2-hydroxy-3-(2-methyloctyl)naphthalene-1,4-dione, which are patterned after Fieser's “10576,” known to be active against the mosquito borne parasite Plasmodium falciparum.
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