Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists

DOI: 10.1021/jm00127a030

Source and publish data:

Journal of Medicinal Chemistry p. 1580 - 1590 (1989)

Update date:2022-08-04

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Authors:

Bigge Bigge

Drummond

Johnson Johnson

Malone Malone

Probert Jr.

Marcoux Marcoux

Coughenour

Brahce Brahce

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Article abstract of DOI:10.1021/jm00127a030

To investigate the preferred spatial relationship of the distal phosphonic acid to the α-amino acid group of the established competitive N-methyl-D-aspartic acid (NMDA) antagonists APH (1) and APV (2), we have prepared a series of ortho-, meta-, and para-

Full text of DOI:10.1021/jm00127a030

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