Synthesis and Cardiac Electrophysiological Activity of N-Substituted-4-(1H-imidazol-1-yl)benzamides-New Selective Class III Agents

DOI: 10.1021/jm00166a003

Source and publish data:

Journal of Medicinal Chemistry p. 1091 - 1097 (1990)

Update date:2022-08-03

Topics:

Authors:

Morgan, Thomas K.

Lis, Randall

Lumma, William C.

Nickisch, Klaus

Wohl, Ronald A.

et al. et al.

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Article abstract of DOI:10.1021/jm00166a003

The synthesis and cardiac electrophysiological activity of 18 N-substituted imidazolylbenzamides or benzenesulfonamides are described.Compounds 6a,d,f-k and 11 exhibited potency in the in vitro Purkinje fiber assay comparable to that of N-<2-(diethylamino

Full text of DOI:10.1021/jm00166a003

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