Synthesis and Cardiac Electrophysiological Activity of N-Substituted-4-(1H-imidazol-1-yl)benzamides-New Selective Class III Agents

DOI: 10.1021/jm00166a003

Source and publish data:

Journal of Medicinal Chemistry p. 1091 - 1097 (1990)

Update date:2022-08-03

Topics:

Authors:

Morgan, Thomas K.

Lis, Randall

Lumma, William C.

Nickisch, Klaus

Wohl, Ronald A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00166a003

The synthesis and cardiac electrophysiological activity of 18 N-substituted imidazolylbenzamides or benzenesulfonamides are described.Compounds 6a,d,f-k and 11 exhibited potency in the in vitro Purkinje fiber assay comparable to that of N-<2-(diethylamino

Full text of DOI:10.1021/jm00166a003

Products guided by the article

Product name:trans-N-<2-(diethylamino)cyclohexyl>-4-(1H-imidazol-1-yl)benzamide

Cas No:120690-01-9

R&D Labs maybe for 120690-01-9

Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Shanghai Zhihua ChemTech Co., Ltd.

Contact:+86-13774313779

Address:Room 817 Suite B 3333 Shenjiang Road
NEM CHEMICAL CO.，LTD

website:http://www.NEM.COM.CN

Contact:+86-393-4411771

Address:The west section of shengli Road,Puyang,Henan Province,China
Weihao Chemtech (ChangZhou) Co., Ltd.(expird)

Contact:051989185693

Address:NO 217 huangshan Rd ,Changzhou
Wuhan Chemchemical Co., Ltd.(expird)

Contact:15973022782

Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.

Relevant to this article

A Single Transition State in the Transfer of the Methoxycarbonyl Group between Isoquinoline and Substituted Pyridines in Aqueous Solution

Doi:10.1021/ja00244a028
(1987)
A highly stereoselective and efficient synthesis of enantiomerically pure sitagliptin

Doi:10.1016/j.tetasy.2016.10.010
(2017)
Favorskii rearrangement of α-chloro β-keto sulfones with amines: A new synthesis of amides and α,β-unsaturated amides from aldehydes and ketons

Doi:10.1016/S0040-4039(00)91645-9
(1992)
(Poly)terephthalates with Efficient Blue Emission in the Solid State

Doi:10.1002/asia.201801619
(2019)
Synthesis of macrobicyclic compounds containing aza-crown ether fragments and study of their complexation with zinc and cadmium nitrates

Doi:10.1007/s11172-011-0156-1
(2011)
Synthesis and properties of seleno-analog MK-organic dye for photovoltaic cells prepared by CH functionalization reactions of selenophene derivatives

Doi:10.1246/cl.2011.978
(2011)

Article Doi