Favorskii rearrangement of α-chloro β-keto sulfones with amines: A new synthesis of amides and α,β-unsaturated amides from aldehydes and ketons

Article abstract of DOI:10.1016/S0040-4039(00)91645-9

The Favorskii rearrangement of α-chloro β-keto sulfones, which are easily synthesized from aldehydes and ketones, with amines gives β-sulfonyl amides in good yield. These β-sulfonyl amides are converted to amides and α,β-unsaturated amides by reduction or elimination of the sulfonyl group.