6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

DOI: 10.1002/jhet.5570250615

Source and publish data:

Journal of Heterocyclic Chemistry p. 1689 - 1695 (1988)

Update date:2022-08-05

Topics:

Authors:

Burpitt Burpitt

Crawford

Davies Davies

Mistry Mistry

Mitchell

Pancholi

Coates Coates

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/jhet.5570250615

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.

Full text of DOI:10.1002/jhet.5570250615

Products guided by the article

Product name:3-Methyl-4-oxo-4-[4-(4-oxo-4H-pyridin-1-yl)-phenyl]-butyric acid methyl ester

Cas No:120757-19-9

R&D Labs maybe for 120757-19-9

Jiangsu Feymer Technology Co., Ltd.

Contact:+86-512-58110132

Address:Fenghuang Town, Zhangjiagang City, Jiangsu Province, China
Shaanxi Sinuote Biotech Co.,Ltd

Contact:+86-29-68859685

Address:No 18,Taiyuan Road ,Xi'an city ,China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Shandong General Materials Co.,Ltd（Shandong Aoertong Chemical Co., Ltd）

Contact:86-531-88072280

Address:No. 1825 Hualong Road, Licheng District, Jinan, Shandong, China
GIHI CHEMICALS CO.,LIMITED

Contact:+86-571-86217390

Address:No.567 Dengcai Street,Sandun,Westlake District,Hangzhou310030,Zhejiang,China.

Relevant to this article

Preparation of cobalt sandwich diphosphine ligand [(η⁵-C₅H₄ⁱPr)Co(η⁴-C₄(PPh₂)₂Ph₂)] and its chelated palladium complex: Application of diphosphine ligand in the preparation of mono-substituted ferrocenylarenes

Doi:10.1016/j.ica.2009.11.010
(2010)
Synthesis of arnoamine B

Doi:10.3987/COM-09-11804
(2010)
THE CATALYTIC EFFECT OF CATIONIC AMINO MICELLES ON THE HYDROLYSIS OF SUBSTITUTED PHENYL ESTERS

Doi:10.1016/S0040-4020(01)81445-9
(1988)
THE EFFECT OF SULPHUR DIOXIDE ON THE MANNICH REACTIONS OF PHENOLS

Doi:10.1016/S0040-4039(00)82196-6
(1988)
The stereodynamics of 1,2-dipropyldiaziridines

Doi:10.1002/chir.20742
(2010)
A Cyclometallated (Azobenzene)palladium(II) complex of 1,4,7- trithiacyclononane: Synthesis and reactivity with thioether-dithiolate metalloligands, single-crystal X-ray diffraction analyses and electrochemical studies

Doi:10.1002/ejic.200900049
(2009)

Article Doi