Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

DOI: 10.1016/j.bmcl.2009.11.111

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 499 - 502 (2010)

Update date:2022-07-30

Topics:

Authors:

Leger, Serge

Black, W. Cameron

Deschenes, Denis

Dolman, Sarah

Falgueyret, Jean-Pierre

Gagnon, Marc

Guiral, Sebastien

Huang, Zheng

Guay, Jocelyne

Leblanc, Yves

Li, Chun-Sing

Masse, Frederic

Oballa, Renata

Zhang, Lei

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Article abstract of DOI:10.1016/j.bmcl.2009.11.111

A series of stearoyl-CoA desaturase 1 (SCD1) inhibitors were developed. Investigations of enzyme potency and metabolism led to the identification of the thiadiazole-pyridazine derivative MF-438 as a potent SCD1 inhibitor. MF-438 exhibits good pharmacokine

Full text of DOI:10.1016/j.bmcl.2009.11.111

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