Efficient and chemoselective protection of alcohols and phenols with tert-butyldimethylchlorosilane (TBDMCS) under solvent-free conditions

Article abstract of DOI:10.1080/10426509808045483

Various types of primary and secondary alcohols and phenols can be converted efficiently to their corresponding TBDMS ethers using TBDMCS/imidazole under solvent-free conditions. Elimination of DMF, accompanied with an easy non-aqueous work-up and a high rate enhancement of the reaction are worthy to be mentioned for the presented method. The reactions show absolute chemoselectivity for the protection of primary in the presence of secondary alcohols.

Full text of DOI:10.1080/10426509808045483

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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EFFICIENT AND
CHEMOSELECTIVE PROTECTION
OF ALCOHOLS AND
PHENOLS WITH Tert-
BUTYLDIMETHYLCHLOROSILANE
(TBDMCS) UNDER SOLVENT-
FREE CONDITIONS
Habib Firouzabadi a , Shahrad Etemadi a , Babak
Karimi a & Ali Asghar Jarrahpour a
a Department of Chemistry , Shiraz University ,
Shiraz, 71454, Iran
Published online: 04 Oct 2006.
To cite this article: Habib Firouzabadi , Shahrad Etemadi , Babak Karimi & Ali Asghar
Jarrahpour (1998) EFFICIENT AND CHEMOSELECTIVE PROTECTION OF ALCOHOLS AND
PHENOLS WITH Tert-BUTYLDIMETHYLCHLOROSILANE (TBDMCS) UNDER SOLVENT-FREE
CONDITIONS, Phosphorus, Sulfur, and Silicon and the Related Elements, 143:1, 45-51,
DOI: 10.1080/10426509808045483
To link to this article: http://dx.doi.org/10.1080/10426509808045483
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