Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues

DOI: 10.1021/jm00045a007

Source and publish data:

Journal of Medicinal Chemistry p. 3033 - 3039 (1994)

Update date:2022-08-04

Topics:

Authors:

Sugimori

Ejima Ejima

Ohsuki Ohsuki

Uoto Uoto

Mitsui Mitsui

Matsumoto

Kawato Kawato

Yasuoka Yasuoka

Sato Sato

Tagawa Tagawa

Terasawa

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Article abstract of DOI:10.1021/jm00045a007

Eleven novel hexacyclic and three 7,9-disubstituted pentacyclic derivatives of camptothecin were synthesized and evaluated for in vitro cytotoxic activity against P388, HOC-21, and QG-56 and in vivo antileukemic activity against P388 in mice. Hexacyclic c

Full text of DOI:10.1021/jm00045a007

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