On the Structure Selectivity Problem in Drug Design. A Comparative Study of Benzylpyrimidine Inhibition of Vertebrate and Bacterial Dihydrofolate Reductase via Molecular Graphics and Quantitative Structure-Activity Relationships

DOI: 10.1021/jm00128a035

Source and publish data:

Journal of Medicinal Chemistry p. 1895 - 1905 (1989)

Update date:2022-08-03

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Authors:

Selassie, Cynthia Dias

Fang, Zhao-Xia

Li, Ren-Li

Hansch, Corwin

Debnath, Gargi

et al. et al.

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Article abstract of DOI:10.1021/jm00128a035

Quantitative structure-activity relationships (QSAR) have been derived fro the action of 68 5-(substituted benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase (DHFR) from Lactobacillus casei and chicken liver.The QSAR are analyzed with respect to th

Full text of DOI:10.1021/jm00128a035

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