On the Structure Selectivity Problem in Drug Design. A Comparative Study of Benzylpyrimidine Inhibition of Vertebrate and Bacterial Dihydrofolate Reductase via Molecular Graphics and Quantitative Structure-Activity Relationships

DOI: 10.1021/jm00128a035

Source and publish data:

Journal of Medicinal Chemistry p. 1895 - 1905 (1989)

Update date:2022-08-03

Topics:

Authors:

Selassie, Cynthia Dias

Fang, Zhao-Xia

Li, Ren-Li

Hansch, Corwin

Debnath, Gargi

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00128a035

Quantitative structure-activity relationships (QSAR) have been derived fro the action of 68 5-(substituted benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase (DHFR) from Lactobacillus casei and chicken liver.The QSAR are analyzed with respect to th

Full text of DOI:10.1021/jm00128a035

Products guided by the article

Product name:4-phenyl-β-cyano-N-phenylcinnamylamine

Cas No:121269-12-3

R&D Labs maybe for 121269-12-3

MTT Pharma & Bio-technology Co.,Ltd(expird)

Contact:+86-21-58407925

Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
Suzhou Sibian Chemical Technology Co., Ltd

website:http://www.sibianpharm.com

Contact:+8618169181984,+8618013186906

Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
SPRING CHEMICAL INDUSTRY CO.,LTD

Contact:86-187-66672125

Address:linchi industry park.zouping
Zibo Jujin Chemical Industry Co., Ltd.（Dongming Jujin Chemical Industry Co., Ltd. ）

Contact:+86-533-2975022

Address:No.99 Shanquan Road, Zhangdian District
Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG

Relevant to this article

Condensed pyridazines. VII. Reaction of 7-(methylsulfonyl)-1-phenyl-1H-imidazo[4,5-d]pyridazine with nucleophiles

Doi:10.1248/cpb.37.13
(1989)
A Bio-inspired Approach for Chromophore Communication: Ligand-to-Ligand and Host-to-Guest Energy Transfer in Hybrid Crystalline Scaffolds

Doi:10.1002/anie.201507400
(2015)
Tandem ring-closing/cross-metathesis approach for the synthesis of synargentolide B and its stereoisomers

Doi:10.1002/ejoc.201300434
(2013)
Facile synthesis of imidazo[1,2-a]pyridines via tandem reaction

Doi:10.3987/COM-09-11856
(2010)
Synthesis and studies of hydrolysis of p-nitrophenyl picolinate catalysed by schiff base zinc (ii) complexes with aza-crown ether or morpholinopendants

Doi:10.3184/030823409X450525
(2009)
Highly enantioselective aldol reaction of acetaldehyde and isatins only with 4-hydroxydiarylprolinol as catalyst: concise stereoselective synthesis of (R)-convolutamydines B and E, (-)-donaxaridine and (R)-chimonamidine

Doi:10.1016/j.tet.2009.12.041
(2010)

Article Doi