Efficient Synthesis of Sterically and Optically Pure E,Z Conjugated Hydroxy Dienes. A New Approach to Hydroxyeicosatetraenoic Acids

Article abstract of DOI:10.1021/jo00275a022

A new strategy for the synthesis of optically active E,Z conjugated hydroxy dienes, important intermediates for the synthesis of HETEs, is described.It involves as its key steps two successive chirality transfers starting from the tricyclic lactol 5, easi